Title: Claudin-5-binders enhance permeation of solutes across the blood–brain barrier in a mammalian model
نویسندگان
چکیده
Affiliations: Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan (Y.H., K.S., Y.O., A.W., T.D., K.Y. and M.K.) Proteo-Science Center, Ehime University, Ehime, 790-8577, Japan (H.T. and T.S.) Life Science Research Laboratories, Wako Pure Chemical Industries, Ltd., Hyogo, 661-0963, Japan (K.E., M.T. and Y.S.) This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on August 17, 2017 as DOI: 10.1124/jpet.117.243014
منابع مشابه
Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model.
A current bottleneck in the development of central nervous system (CNS) drugs is the lack of drug delivery systems targeting the CNS. The intercellular space between endothelial cells of the blood-brain barrier (BBB) is sealed by complex protein-based structures called tight junctions (TJs). Claudin-5 (CLDN-5), a tetra-transmembrane protein is a key component of the TJ seal that prevents the pa...
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Claudins are a family of integral membrane proteins of the tight junction that are thought to participate in the permeation of solutes across epithelia via the paracellular pathway. Claudin-8 is expressed in the distal renal tubule, which has a characteristically low passive permeability to monovalent cations. To test the hypothesis that claudin-8 plays a role in forming a tight paracellular ba...
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Tight junctions (TJs) are complex biochemical structures that seal the intercellular space and prevent the free movement of solutes across epithelial cell sheets. Modulating the TJ seal is a promising option for increasing the transdermal absorption of drugs. Within TJs, the binding of the claudin (CLDN) family of tetratransmembrane proteins through cis- and trans-interactions is an integral pa...
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PURPOSE Changes in blood vessel barrier properties contribute to retinal edema in diabetic retinopathy (DR). However, limited data are available to describe the routes of transport for fluids and solutes across the inner blood-retinal barrier (iBRB). In this study, a three-pore model was developed to characterize such routes in normal and elevated glucose levels. METHODS Diffusive and apparen...
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